Diabetes is not considered a rather dangerous disease for nothing – several million people around the world die from it every year. It is impossible to cure this disease, but it is possible to maintain the patient’s state of health at a quite acceptable level through the use of special drugs. In recent years, pharmacology has made great advances in this direction, so the choice of remedies is quite large. With their help you can keep blood sugar under complete control.
Today we want to talk about the most widely used drugs of this type – we have devoted to this rating of the best drugs for controlling blood sugar. In this article, we will detail the useful qualities of the most well-known medications, as well as give some important tips on the proper selection of drugs. However, in any case, our readers should remember that it is strictly forbidden to treat diabetes on their own, so the course of treatment must necessarily appoint a medical professional.
How to choose the right drug for blood sugar normalization?
It should be noted that a healthy person’s blood sugar level is always about the same and does not exceed certain limits, regardless of whether he wants to eat or just took a portion of food. Generally, a value between 2.5 mmol/l and 8 mmol/l is considered normal.
In the old days, when mankind was not yet able to treat diabetes mellitus, those who fell ill after a few years developed ketoacidotic company, the result of which was death. Today, such cases are quite frequent, because the principle of action of all drugs is aimed to prevent the sugar level from rising to critical values.
To date, in pharmacies you can find several main groups of drugs used to combat the manifestations of type 2 diabetes mellitus. They differ from each other in the mechanism of action. There are drugs that stimulate the production of additional amounts of insulin by the pancreas, others increase the sensitivity of the body’s cells to insulin. You can find drugs that reduce the amount of glucose produced by the liver and its entry into the blood, the next group reduces the amount of carbohydrates absorbed by the intestine. The latter type promotes the excretion with the urine of excess glucose.
When we chose drugs for inclusion in our rating of the best drugs for normalizing blood sugar levels, we took into account all the points discussed above. In this review we decided to include far from the most expensive drugs, so that our readers will be able to choose the best option for themselves in all respects. We hope that after a thorough study of the article and consultation with a specialist, you will be able to choose the best option for yourself or your loved one.
The 10 best pills for normalizing blood sugar
10. Maninil 5
Available as pale pink colored tablets, they are flat-cylindrical in shape, with beveled edges and a risk on one side. The main active ingredient here is gibenclamide in micronized form. One tablet contains 5 mg of the substance. As auxiliary compounds used here is gelatin, potato starch, talc, crimson dye, lactose monohydrate and magnesium stearate. The drug stimulates insulin production by binding to receptors on pancreatic cell membranes. In addition, the drug increases the body’s sensitivity to insulin. It increases the activity of insulin itself, allowing it to directly affect the degree of glucose absorption by muscle and liver cells, which leads to lower blood glucose concentrations.
Absorbed in the gastrointestinal tract almost immediately – the effect of the drug is felt literally in 5 minutes. Completely eliminated from the body within 16 hours. Taken two hours after a meal, the dose can be increased if necessary. Side effects include hypoklemia, which is manifested by a constant feeling of hunger; some nausea may occur.
- The action is almost instantaneous;
- Promptly eliminated from the body;
- Minor side effects;
- One pack is enough for a long time;
- Reasonable cost;
- Long-lasting positive effect.
- There are a number of contraindications;
- The dose will have to be increased over time.
The drug is a white rounded tablets with slightly beveled edges. The active ingredient here is gliquidone – one tablet contains 30 mg. Auxiliary compounds used here include completely dried corn starch, soluble corn starch and lactose monohydrate. It is optimal for type 2 diabetes. With its help, the pancreas begins to actively produce insulin, the pills are also characterized by pancreatic and extrapancreatic action. Hypoklemic effect is observed about an hour to an hour and a half after taking the drug, the maximum effect of the drug comes on average in two to three hours, the duration is about 10 hours.
The active substance has a high affinity compared to proteins contained in the plasma. It does not pass through the placenta, does not enter the breast milk, so the drug is approved for use by pregnant women. This medication is often prescribed for middle-aged and elderly people if diet therapy does not work.
- The active ingredient is similar to plasma proteins – easily absorbed by the body;
- Long-lasting positive effect;
- Suitable for pregnant women;
- Compact form factor – easy to take by mouth.
- Relatively expensive drug;
- Not suitable for patients under 18 years of age.
The drug has been available in pharmacies for ten years, but it still has not lost its relevance and is able to outperform many more modern tools. The drug is a white tablet with a yellowish or cream color, there is a bevel, the shape is flat-cylindrical. The active ingredient here is gliclazide, in one tablet its 80 mg. As auxiliary compounds, lactose monohydrate, microcrystalline cellulose, potato starch, hypromellose, magnesium stearate, talc, and sodium carboxymethyl starch are added to the drug. After taking the drug, an increase in the sensitivity of peripheral tissues to insulin is observed. It helps to reduce the rise in glucose levels after a meal.
The drug improves blood microcirculation, restores vascular permeability and prevents the development of microthrombosis and atherosclerosis. Absorbed from the gastrointestinal tract almost immediately, the maximum effect occurs after two to three hours, lasting up to one day, within two days the substance is completely eliminated from the body.
- Does not allow increase in blood glucose levels;
- It is absorbed into the bloodstream quickly enough;
- Reasonable cost;
- Has a number of auxiliary positive effects.
- Not suitable for pregnant and lactating women;
- People with hypersensitivity should also refrain from taking this drug.
7. Diabeton MV
The drug has a modified release, so the positive effect comes much faster compared to other drugs. It is made in the form of white, biconvex tablets of oval shape, there is a notch and engraving. The active ingredient – gliclazide, one tablet contains 60 mg, and the drug also contains lactose monohydrate, maltodextrin, hypromellose, magnesium stearate, colloidal silicon dioxide with zero moisture content. The tablets easily cope with the normalization of blood glucose concentrations, after taking them insulin begins to be produced most actively. Increased concentration of insulin is observed in the body after a two-year theramia.
The drug reduces the risk of thrombosis in small vessels, improves the cardiovascular system in general. The positive effect of taking it is achieved by reducing the key microvascular complications that often occur in diabetic patients, the normalization of kidney function. Maximal level of action of the drug lasts for 10-12 hours. Food intake at the same time does not affect the speed or volume of the absorbed active ingredient.
- Convenient to use form-factor;
- Long-lasting positive effect;
- Minimization of microvascular complications from diabetes.
- It is eliminated from the body naturally for quite a long time;
- Not to be taken by children and pregnant women.
Despite its high cost, this drug is very popular among doctors and patients. The drug copes very well with its intended function. It comes in the form of pinkish tablets of oblong shape, they are flat, on each side there is a separating risk and engraving. The active compound here is glimepiride – one tablet contains 1 mg. In addition, the drug contains lactose monohydrate, sodium carboxymethyl starch, povidone, microcrystalline cellulose, magnesium stearate. The function of the dye here is iron oxide red.
The product increases the sensitivity of the cells of the pancreas to glucose stimulation, which in turn leads to increased insulin production. In addition, the active ingredient contained here normalizes the content of lipids, preventing their peroxidation, atherosclerotic plaques virtually stop forming. Absorption in the gastrointestinal tract is complete.
- Quickly begins to act;
- Reduces the number of atherosclerotic plaques;
- All ingredients are safe for health;
- Long lasting effect.
- High cost;
- Not suitable for pregnant and nursing women.
It is a last generation oral medication, characterized by a short-term action. Almost immediately after use, blood glucose levels fall due to rapid stimulation of the pancreatic cells. The main active ingredient is repaglinide, which blocks the ATP-dependent potassium channels. Maximal effect is observed after half an hour of usage. Blood glucose levels are reduced during meals, and insulin concentrations will not rise. Absorbed in the gastrointestinal tract within minutes, the plasma concentration also increases quite quickly.
The drug is fully eliminated from the body in only six hours, and the half-life period does not exceed one hour. Perfect for people suffering from type 2 diabetes, but positive effect cannot be achieved by weight reduction, diet and regular physical exercises. It should be taken 15 minutes before a meal.
- It starts to work very quickly;
- After a few hours is completely eliminated from the body;
- Practically has no contraindications and side effects;
- Reasonable cost.
- The effect of taking this medication is short-lived.
It is available strictly by prescription, you will not find this drug on the market. This is the first drug in our review that contains two active substances at once – metmorphine and glibenclamide. The first formula belongs to the biguanide group. It lowers glucose levels by increasing the sensitivity of peripheral tissues to the effects of insulin; accordingly, glucose will be taken up more actively. In the gastrointestinal tract, the level of absorbed carbohydrates decreases, the synthesis of glucose in the liver slows down, the substance lowers the total level of cholesterol.
Glibenclamide inhibits lipolysis in fat tissues, the maximum concentration of the drug in the body occurs after one to two hours, the duration of the positive effect is about 10 hours. The drug is completely eliminated from the body within 10-16 hours. Available as pills, one pack may contain from 10 to 120 pills.
- Contains two active substances at once;
- The effect lasts for a long time;
- No problem with elimination from the body;
- Has a number of other positive effects on the body.
- Quite a large number of contraindications.
In third place is a remedy containing repaglinide, which acts as an active compound. In addition to it, there are a number of excipients – meglumine, corn starch, iron oxide yellow, iron oxide red, microcrystalline cellulose, magnesium stearate, glycerol, povidone, poloxamer, potassium polacrylin and dehydrated potassium hydrophosphate. The drug is manufactured in the form of tablets that are white in color. They are round in shape, convex on both sides. Absorption occurs in the stomach and upper intestines, so the positive effect occurs very quickly. The maximum concentration is reached approximately one hour after ingestion, and the drug is completely eliminated from the body within 4-6 hours.
The active substance is absorbed very quickly, the drug is suitable even for patients with renal failure, although some concentration of the drug may remain if the form of failure is severe. The drug can be easily combined with diet and exercise and is taken orally about 15 minutes before a meal.
- Quickly starts to work;
- Easily removes excess glucose from the blood;
- It is eliminated in just a few hours;
- Low price.
- Some patients experience intolerance to some components of the drug.
The form factor is oval biconvex film-coated tablets that are white or slightly yellowish in color. One tablet contains 500 mg of metmorphine hydrochloride; the medicine also contains: povidone, crosspovidone, stearic acid and colloidal silicon dioxide. The shell is made of macrogol, hypromellose and talc. The drug actively inhibits gluconeogenesis, increases the amount of free fatty acids synthesized by the body and accelerates fat oxidation. Almost immediately peripheral receptor sensitivity to insulin increases, cells begin to actively absorb and utilize glucose.
Methmorphine itself does not affect the amount of insulin in the blood, but it does affect its pharmacodynamics. Against the background of taking this medication, body weight either remains the same or begins to decrease moderately. In the tissues of the body the product is distributed evenly, does not bind with plasma proteins and is excreted naturally almost in its original form. After taking the drug, the patient almost immediately begins to feel significantly better – insulin levels stabilize, respectively, the concentration of glucose is normalized.
- Easy to take;
- Does not accumulate in the body;
- Is excreted naturally;
- Has an active effect on insulin synthesis.
Diabetes Exercises At Home Workout: To Help Control Diabetes (Level 1)
- Approach the reception of this medicine should be very carefully – there are many side effects and contraindications.
The drug is prescribed in the complex therapy of diabetes mellitus. Improves glucose control without the risk of hypoglycemia, protects blood vessels. Activates insulin receptor – increases the number of active receptors on the cell surface. Improves peripheral microcirculation.
- Complex action;
- Compatibility with other drugs;
- Fast action.
- Individual intolerance.
Useful video in the conclusion
Here we come to the end of our review of the best medications for controlling blood sugar. In conclusion, I would like to remind you once again that it is strictly forbidden to buy and take such medicines on one’s own. You should consult your doctor before doing so. Do not self-medicate, otherwise the consequences can be very deplorable. If there are any questions about the drugs presented in the rating, then feel free to ask us in the comments to the article – we will try as soon as possible to provide you with additional information.
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